A kinetic model for USP14 regulated substrate degradation in 26S proteasome
Fig 5
Effects of USP14 on substrate preference in proteasomal degradation.
The preference ratio η in Eq. 8 is illustrated in the relative rate space versus
(A), and in
versus
space (B). The black dashed line indicates
where the degradation preferences of substrate S to T in USP14-bound and USP14-free proteasomes are equal. Parameters:
for (A), and
for (B).