Prioritization of causal genes from genome-wide association studies by Bayesian data integration across loci
Fig 5
GWAS loci with Mendelian evidence.
SigNet selects the gene with Mendelian evidence (green rectangle) over the closest gene in the locus to a GWAS SNP (gray rectangle). Pink ovals represent genes with Mendelian evidence; yellow ovals represent colocalized genes; white ovals represent information-poor genes; and gray lines represent protein-protein interactions. Networks are shown for three individual loci, highlighting the gene selected by SigNet: (a) CACNA1C, (b) KCNQ1, (c) SLC4A3.