Intraneuronal binding of amyloid beta with reelin—Implications for the onset of Alzheimer’s disease
Fig 6
Recapitulating the effects of miRNA intervention in Re+alECLII neurons of McGill-R-Thy1-APP rats.
Panels A and B are identical with panels 1 and 4 in Fig 4A in reference [8]. The black vertical lines denote the mean values of the distributions in the experimental group of neurons. The green vertical lines denote the mean values of the distributions in the control group of neurons. The ratios of the mean values of the experimental group to the mean values of the control group are 0.26 and 0.69, respectively. C. Predicted steady state total number of reelin in experimental neurons as a function of the fold change of αbaseline in transgenic rats (Tg) compared to wild type and the fractional decrease of τ relative to wild type. Only a small subset of the fold change values and the fractional change values used in the numerical study is shown. The vertical dashed line denotes the predicted fractional reduction in the reelin production rate relative to wild type (0.14) that best fits the data. The horizontal dashed line denotes the total copy number of reelin when the fold change is 2.57. D. Predicted steady state total copy number of Aβ42 in experimental neurons as a function of the fold change of αbaseline relative to wild type and the fractional decrease of τ relative to wild type. The horizontal dashed line denotes the total copy number of Aβ42 when the fold change is 2.57.