Intraneuronal binding of amyloid beta with reelin—Implications for the onset of Alzheimer’s disease
Fig 4
Immune response in Re+alECLII neurons with the COLBOS reelin mutation.
The parameter values are identical with those of the ApoEϵ3/ϵ3 genotype, except that γ=0.0000001, i.e., we assume that the reelin mutation is genetically dominant and causes a dramatic reduction in affinity between reelin and Aβ. The four panels show how the levels of free Aβ, free reelin, Aβreelin and the proportion of phosphorylated GSK3β develop during an infection event lasting 120 hours (from t = 50 to t = 170). See the main text for further explanation.