The tumour histopathology “glossary” for AI developers
Fig 3
Example of computational modelling of an oncologic precursor lesion (low-grade dysplasia (LGD), human colon) with feature extraction.
(A) Conventional features of (sporadic) colonic LGD, i.e., hyperchromasia, next to normal colonic mucosa (separated by black line) with inconspicuous enterocytes and crypts (representative example of an inflammatory bowel disease cohort, HE stain). Arrows: Hyperchromatic, pseudostratified (pencillate) nuclei in LGD. (B) Nuclei detection, produced using a deep neural network [77]. Inset: High magnification. (C) Nuclei intensity mapping. Computed from the segmentation mask in B by normalising the nuclei intensities across the whole slide image. LGD shows higher intensities, histologically corresponding to hyperchromasia (darker staining in HE).