In silico biophysics and rheology of blood and red blood cells in Gaucher Disease
Fig 7
Schematic diagram of different RBC stiffness (A) and corresponding simulation results (B and C) of the relative viscosity of blood for different RBC stiffness and hematocrit levels with disaggregation threshold of 250s−1.
A) Representation of three different levels of cell stiffness through different shear modulus conditions at a shear stress of 1 dyn/cm2. B) The steady shear relative viscosity versus imposed shear rate for three different hematocrit levels and three different cell stiffness at each hematocrit. The viscosities are normalized by the plasma viscosity; the effect of cell stiffness increases at high shear rates, and the deformation of cells becomes increasingly more dominant C) Relative viscosity against hematocrit for different shear rates and three different RBC stiffness of 20, 9, and 4 Es0.