A mathematical model of plasmin-mediated fibrinolysis of single fibrin fibers
Fig 5
Degradation pattern for four different parameter sets.
Snapshots were taken when the percentage of degraded doublets in the cross-section was 18%, 36%, 54%, and 72%, from left to right. Each pixel represents a protofibril. The color bar indicates the number of degraded doublets at the given protofibril from 0 (blue) to 6 (yellow). The small red square shows the initial location of plasmin and the small black square shows where degradation first occurred. A: Baseline parameter values. B: Lower unbinding rate (kunbind = 0.01 s−1), other parameters at baseline values. C: Higher crawling rate (kcrawl = 120 s−1), other parameters at baseline values. D: Higher degradation and exposure rates (kdeg = kexp = 45 s−1), other parameters at baseline values.