A multivalent binding model infers antibody Fc species from systems serology
Fig 6
Inferred IgG fucosylation correlates with HIV severity and is lower for membrane-associated antigens.
(a), (b) Inferred IgG fucosylation by target antigen and patient status for HIV-infected subjects. (c) Inferred IgG fucosylation by antigen type. (d) Inferred IgG fucosylation by antigen type and patient status. (e) IgG fucosylation was inferred for each sample and antigen. The fucosylation inferences for each antigen were compared across samples and used to compute a Pearson correlation coefficient. The pairwise correlation in IgG fucosylation between each antigen is shown. A Mann–Whitney U-test was used to define differences and the Benjamini–Hochberg method was used to adjust for multiple comparisons, with an adjusted .