Circuits and mechanisms for TMS-induced corticospinal waves: Connecting sensitivity analysis to the network graph
Fig 10
Analysis to select a time-step that both minimizes computation time and is numerically stable.
Each scatter-line plots shows the mean of a metric as a function of the time-step size in the log10 scale. At the bottom, the membrane potentials of the neuron model for different time-steps are shown. Offsets were added for the y-axis to allow all lines to be distinctly seen. The plots depict a key behavior that differentiates simulations at larger time steps. A pronounced afterhyperpolarization is seen with a 0.2 ms time-step that is absent from other time-steps. Additionally, spikes are generated at larger time-steps (0.1 and 0.2 ms) that are absent for smaller time-steps. These dynamics contribute to the larger numbers of spikes, lower mean ISIs, larger NRMSE, and larger spike distance observed for larger time-steps.