Circuits and mechanisms for TMS-induced corticospinal waves: Connecting sensitivity analysis to the network graph
Fig 6
Sensitivity was computed as the average effect size for a specific corticospinal wave across all relevant mechanisms. A) Sensitivity was divided based on activation vs the synaptic strengths of the network. B) Sensitivity to activation was divided into feedforward activation, i.e., activation of extracortical afferent terminals, and feedback activation, i.e., activation of the motor cortical circuit. C) Sensitivity to the synaptic strengths was divided into the feedforward circuit, i.e., the synaptic strengths of extracortical afferents, vs the feedback circuit, i.e., the synaptic strengths of intracortical projections. D) Sensitivity was divided into elements that were excitatory vs inhibitory. E) Feedforward activation was divided into feedforward excitation, i.e., afferents targeting excitatory neurons, vs feedforward inhibition, i.e., afferents targeting inhibitory neurons. F) The synaptic strengths were divided into synaptic strengths of afferents targeting excitatory neurons vs synaptic strengths of afferents targeting inhibitory neurons. G) Feedback activation was divided into feedback excitation, i.e., activation of excitatory motor cortical neurons, vs feedback inhibition, i.e., activation of inhibitory motor cortical neurons. H) The synaptic strengths were divided into the strengths of excitatory intracortical projections vs inhibitory intracortical projections. Note the differences in y-axis values.