Rapid prediction of key residues for foldability by machine learning model enables the design of highly functional libraries with hyperstable constrained peptide scaffolds
Fig 9
Functional and selective inhibitors against HtrA1 generated from 5JI4 libraries.
A. Sequences for HtrA1 primary hit and affinity maturation hits with Spot ELISA, SPR measured Kd and IC50 measured by enzymatic assay. B. Inhibition of HtrA1 enzyme activity by HCP derived from 5JI4 libraries.