Evolutionary history of calcium-sensing receptors unveils hyper/hypocalcemia-causing mutations
Fig 5
Specific conserved residues mapped onto structures.
The cryo-EM structure of human CaSR bound with Ca2+and L-Trp (PDB:7DTV) and homology models of GPRC6A, TAS1R1, TAS1R2 and TAS1R3 are colored based on SDP scores. Residues with a high SDP score (above 5.0) are shown as spheres. Domains on the human CaSR structure (PDB: 7DTV) are labeled and colored according to their SDP scores on the right-hand side.