Evolutionary history of calcium-sensing receptors unveils hyper/hypocalcemia-causing mutations
Fig 2
(A) The maximum likelihood phylogenetic tree of Class C GPCRs, spanning representative species from each subfamily, is shown. Subfamilies are represented as circular layers around the ML tree. All twenty-two Class C GPCR subfamilies are shown in the inner circle. In addition to these subfamilies, vomeronasal and other orphan receptors are represented as CaSR-like receptors. All proteins in CaSR, GPRC6A and TAS1Rs are merged into this representative species tree. (B) Branch lengths from leaf to root of the common species that exist in all CaSR, GPRC6A and TAS1Rs are taken from the subfamily trees. Welch’s t-Test using the ggstatsplot package results are shown on the graph.