Detectability of runs of homozygosity is influenced by analysis parameters and population-specific demographic history
Fig 7
Comparison between empirical and simulated declining population across coverages.
In all tools, FROH is consistently underestimated. Increasing coverage from 5X to 10X can have significant effects on FROH estimates. A-C) Inferred FROH values for declining population data and D-F) inferred FROH values for empirical data at varying coverage levels for all three methods. True mean FROH values for simulated data are indicated by horizontal dashed line. For the simulated data, error bars are bootstrapped 95% CIs and points represent mean values, lines for 15 randomly subsampled individuals are displayed for simplicity. For the empirical results, points represent mean values (n = 15) and error bars correspond to 95% CIs.