Detectability of runs of homozygosity is influenced by analysis parameters and population-specific demographic history
Fig 5
All three methods tested combine multiple true ROHs into single called ROHs, with increasing coverage only providing improvements for BCFtools Likelihoods.
A) Diagram illustrating this lumping issue. B) Examples of this issue at 5X and 50X in a single simulated individual drawn from the small population demographic scenario. C) Number of true ROHs combined into a single called ROH for ROHs of varying lengths when called by all three methods at 5X and (D) at 50X in the small population (results for all coverage levels and demographic scenarios provided in S16 Fig). Points correspond to mean values and vertical and horizontal error lines indicate 95% confidence intervals. Dashed horizontal line corresponds to y = 1 (a 1:1 relationship between numbers of true and called ROHs).