Capturing cell heterogeneity in representations of cell populations for image-based profiling using contrastive learning
Fig 6
CytoSummaryNet profiles make readily identifiable mechanisms of action even easier to find and allow for the discovery of previously unfindable mechanisms of action when using average-aggregated profiles (cpg0004 dataset).
Mean average precision (mAP) of average and CytoSummaryNet-based profiling for mechanism of action retrieval of 3.33 μM (test) and 10 μM (training/validation) dose point compound perturbations. We highlight certain high-performing mechanisms of action. Data points are scaled in size based on the number of compounds labeled with that mechanism of action (MoA).