Capturing cell heterogeneity in representations of cell populations for image-based profiling using contrastive learning
Fig 5
CytoSummaryNet profiles generally outperform average-aggregated profiles in mechanism of action (MoA) retrieval, although not for out-of-distribution batch data (Stain5).
The box plots illustrate the average mAP of mechanism of action retrieval for CytoSummaryNet- (dark purple) and average- (light pink) aggregated profiles (each data point is the average mAP of a plate). Welch’s t-tests were used to compare the means between CytoSummaryNet and average mAP scores; their p-values are indicated as stars inside each plot (ns = not significant). The limited number of data points, due to averaging mAP scores per plate, may impact the statistical significance of the comparisons.