Capturing cell heterogeneity in representations of cell populations for image-based profiling using contrastive learning
Fig 3
CytoSummaryNet profiles generally outperform average-aggregated profiles for sensitively identifying replicates of a given sample, and partially generalize to unseen experimental protocols (test plates).
The box plots illustrate the mAP of replicate retrieval for all validation compounds of Stain3 (each data point is the average mAP of a plate) by CytoSummaryNet (dark green) and average (light green) profiles. Note that although the panels are labeled “training plates” and “validation plates”, all data shown comes from validation compounds and therefore none of it has been directly seen during training (see description of stratification in Results for further details). Welch’s t-tests were used to compare the means between CytoSummaryNet and average mAP scores on corresponding data; their p-values are indicated as stars at the top of each plot (ns = not significant).