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Metabolic cross-feeding interactions modulate the dynamic community structure in microbial fuel cell under variable organic loading wastewaters
Fig 3
Differences in metabolic fluxes within the microbial community under H-OLR and L-OLR conditions.
The major metabolic cross-feedings (
) and intracellular flux (
) differences are represented as flux fold changes (FFCs; denoted as a number in rounded rectangles). The color of red and blue represent positive (+) and negative (-) FFCs, indicating increase and decrease of a reaction flux change in H-OLR, respectively. Intensity levels represent the degree of change, categorized as low (0.00<|FFC|<0.64), medium (0.64≤|FFC|<2), and high (|FFC|≥2) relative to the uptake rate of butyrate (0.64 FFC). Metabolites marked with yellow circles represent model input (data-specific conditions). 
is exchange reaction flux of the metabolite i in community compartment (COM) and the microbial group k including sulfate-reducing bacteria (SRB), methanogen (MET), and sulfide-oxidizing bacteria (SOB). 
is intracellular reaction fluxes of reaction j in the microbial group k including SRB, MET, and SOB. Abbreviations: SRB = sulfate-reducing bacteria, MET = methanogens, SOB = sulfide-oxidizing bacteria, COM = community compartment, Acoad1 = acyl-CoA dehydrogenase, Hacd1 = 3-hydroxyacyl-CoA dehydrogenase, ATPase = ATP synthase, Apr = adenylylsulfate reductase, Dsr = dissimilatory sulfite reductase, Pfor = pyruvate:ferredoxin oxidoreductase, Pepc = phosphoenolpyruvate carboxylase, Fpo = F420H2 dehydrogenase, Mtr = methyl transferase, and Hdr = heterodisulfide reductase.
doi: https://doi.org/10.1371/journal.pcbi.1012533.g003