A flexible generative algorithm for growing in silico placentas
Fig 10
Elementary effects (EE) results for the generation of villous vessels within a placentone employing the input parameter ranges from Table 1.
Input parameters are listed and color-coded at the end of the Figure. Each subplot corresponds to one output metric indicated by subplot titles. For each output metric, the standard deviation (σ) associated with the EE of a certain input parameter is plotted in function of the respective mean (μ*). The σ/μ ratio is shown by dotted lines in all plots. Clusters of highly influential input parameters, as determined by Eq 18, are circled in black. Key: V, placental volume; 2thalf, placental thickness; ds, stem diameter; ltdv, villous length-to-diameter ratio; kv, villous Murray’s Law bifurcation exponent; θpd, parent-daughter branching angle; θdd, daughter-to-daughter branching angle; CCr, central cavity radius; CCh, central cavity height; cf1, cf2, global distribution penalty weights.