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Distribution of calbindin-positive neurons across areas and layers of the marmoset cerebral cortex

Fig 7

Relations between the laminar distribution of CB+ neurons and large-scale trends in cortical organization.

(A) The d2,3/ d5,6 ratios were strongly correlated with the area’s hierarchical level, derived from the laminar pattern of connections. This demonstrates that the bias towards higher density of CB+ neurons in supragranular layers was most marked in low-level (e.g. purely sensory) areas, and more subtle in association and premotor areas. (B) In parallel, the d2,3/ d5,6 ratios varied systematically with respect to the classification of an area according to the degree of laminar differentiation. Analyses of the laminar distribution of CB+ neurons. (C) In contrast with (A), there was no significant correlation between d2,3/ dL4 and hierarchical level. (D) Analysis of d2,3/ d4 relative to the degree of cortical lamination indicated significantly lower d2,3/ d4 ratios (i.e. higher relative concentrations in layer 4) in koniocortex and eulaminate 3 areas, compared to others.

Fig 7

doi: https://doi.org/10.1371/journal.pcbi.1012428.g007