Distribution of calbindin-positive neurons across areas and layers of the marmoset cerebral cortex
Fig 3
Variation in the density of calbindin-positive (CB+) neurons across the marmoset cortical areas.
(A) Density (neurons·mm-3) of CB+ neurons across areas, grouped according to the classification proposed by [45]. For each box plot, the center line indicates the median, the box limits the upper and lower quartiles, the whiskers 1.5× the interquartile range, and the annotated points outliers). Abbreviations: DLP: dorsolateral prefrontal cortex; VLP: ventrolateral prefrontal cortex; OFC: orbitofrontal cortex; MPC: medial prefrontal cortex; MPM: motor and premotor cortex; INS: insular cortex; SSC: somatosensory cortex; AUD: auditory cortex; LIT: lateral and inferior temporal cortex; VTC: ventral temporal cortex (encompassing parahippocampal, perirhinal and entorhinal areas); PCR: posterior cingulate and retrosplenial cortex; PPC: posterior parietal cortex; VIS: visual cortex. (B) Top left: the relation between the absolute density of CB+ neurons and total neuronal density (NeuN staining) in different areas. Top right and bottom: relations between relative and absolute densities of CB+ neurons in 3 animals. (C) Percentages of CB+ neurons across groups of areas, classified as in panel A. (D) Flat map representation of the CB+ neuronal density (mean of all 3 animals) in different areas. Some of the cortical areas are identified for orientation. (E, F) The relation between the absolute and relative densities of CB+ neurons and hierarchical level derived from laminar patterns of connections between cortical areas [36]. (G) Differences in relative density of CB+ neurons between areas according to the degree of lamination (adapted from [43]). Abbreviations: Agr: agranular areas; Dys: dysgranular areas; Eu1, Eu2, Eu3: eulaminate areas with increasing levels of laminar differentiation; Kon: koniocortical areas. Colors in B, E, and F correspond to those in A and C; see S1 File for a full list of areas, color coding and abbreviations.