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Contributions of mechanical loading and hormonal changes to eccentric hypertrophy during volume overload: A Bayesian analysis using logic-based network models

Fig 7

Effects of receptor blockers on VO-induced hypertrophy in published experiments and the calibrated model.

a) Simulations of β blockers (βB) at both early and late stages of VO, simulations (boxplots) were equally likely to predict increases or decreases, with no net effect on average. MR experiments in dogs (circles) [15,16,80] and VO in rats (triangles) [14,124] also found no significant effect early but a further increase in growth at later timepoints relative to untreated VO. b) Simulated administration of angiotensin receptor blockers (ARB) also produced mixed results, consistent with mixed results in published studies [29,42,46,50]. By contrast, simulated ERA administration decreased VO-induced hypertrophy in the majority of simulations, and in all four available experiments [125–128]. Blue coloring of boxplot indicates predicted decrease in >75% of simulations, gray boxplots indicate mixed simulation results, filled markers indicate experimental means associated with statistically significant effects and open markers indicate means associated with non-significant effects.

doi: https://doi.org/10.1371/journal.pcbi.1012390.g007