Contributions of mechanical loading and hormonal changes to eccentric hypertrophy during volume overload: A Bayesian analysis using logic-based network models
Fig 5
Results of MC simulations of VO and agonist infusion.
Top panels show normalized growth in CellArea for 100 representative simulations (gray lines), with terminal values indicated by black circles; adjacent boxplots reflect the mean, CI50, and CI90 of terminal values for 1000 simulations of a) Untreated VO, c) ISO infusion, and e) AngII infusion. Bottom panels contain heatmaps comparing the predictions of changes in signaling network outputs (SERCA, αMHC, βMHC, ANP, BNP, and CellArea) to experimental data following b) Untreated VO, d) ISO infusion, and f) AngII Infusion. Red indicates that more than 75% of simulations predicted an increase in the output, or that the majority of studies reported a significant increase. Blue indicates a decrease in >75% of simulations or the majority of experiments. Gray indicates the absence of consistent changes in simulations or significant changes in experiments. White numbers indicate the number of studies reporting a significant change and the total number of studies reporting data for each output.