Contributions of mechanical loading and hormonal changes to eccentric hypertrophy during volume overload: A Bayesian analysis using logic-based network models
Fig 3
Changes in volume, mass, and end-diastolic strain during experimental MR in dogs.
a) Fitted data on fold changes show a) a 36% increase in LVM [15,16,20–33] and b) 67% increase in LV end-diastolic volume (VED) [16,17,20–26,29,32,33,61,78,80,82,83,131–136] on average at steady-state. c) In a spherical model, these changes imply a 20% increase followed by a gradual decrease below baseline in end-diastolic strain on average, with a wide range of trajectories possible for different combinations of mass and volume change. d) Calculated chronic strain levels are lower when LVM increases more. Insets in panels (a-c) show acute changes plotted on a magnified time axis.