Contributions of mechanical loading and hormonal changes to eccentric hypertrophy during volume overload: A Bayesian analysis using logic-based network models
Fig 2
Effects of inflation and growth on end-diastolic stretch relative to unloaded state in a spherical model and in hearts fixed at control volumes.
a) Spherical model predicts that stretch increases with inflation (black solid line), while eccentric hypertrophy shifts the stretch-volume curve downwards, to lower stretch at any given volume (red dashed line). b) Experimental measurements of sarcomere stretch in dog hearts fixed at controlled volumes similarly show increased stretch between physiological loading conditions (Baseline) and acute volume overload (Acute dilation), and a shift in the stretch-volume relationship following 10% growth in LVM during long-term volume overload. Figure generated based on data from Ross et al. [66].