pyPAGE: A framework for Addressing biases in gene-set enrichment analysis—A case study on Alzheimer’s disease
Fig 6
Association of activation of post-transcriptional regulation programs with survival of patients with AD.
(A) Heatmap representing differences in the activity of the previously identified post-transcriptional regulons in AD samples. Factors which activity is significantly associated with survival are underscored. The dendrogram reflects the results of unsupervised clustering of samples based on activity of factors associated with survival. (B) Kaplan-Meier curve representing the difference in survival between two groups of patients stratified based on the activity of post-transcriptional regulons. (C) Comparison of the activity of selected RBP regulons in healthy samples and samples from two AD clusters. (D) Summary of the Cox regression analysis.