Diffusion model predicts the geometry of actin cytoskeleton from cell morphology
Fig 9
Results from the virtual experiment using the diffusion model.
(A) Comparison of generated SFs with geometrical constraints of aspect ratio (AR = 1 and 3) to experimental results of HFF-1 cells with comparable geometry constraints. The cells in the experimental group have aspect ratios of 1.1 and 2.8, and areas of 1.83 × 103 μm2 and 1.88 × 103 μm2, which are similar to the morphology conditions during the virtual experiments. Scale bars represent 20 μm. (B) Relationship between distance from the geometrically constrained edge r* and probability of generating SFs Pmean for three cases of aspect ratio (AR = 1, 3 and 5). (C,D) Probability distribution function (PDF) of the probability of generating SFs P with a constraint of (C) AR = 1 and (D) AR = 3. (E) Standard deviation σP of P decreases as constraint aspect ratio increases.