Multi-scale modelling of location- and frequency-dependent synaptic plasticity induced by repetitive magnetic stimulation in the dendrites of pyramidal neurons
Fig 8
Distal LTP induced by simulated rMS is sustained by sodium dendritic spikes but less affected by inhibition than local electrical stimulation.
rMS TBS (red) generates LTP even when local electrical TBS (blue) does not. In the presence of simulated GABAergic inhibition, rMS induces LTP comparable to local electrical stimulation without inhibition (i.e. bicuculline simulation). When dendritic sodium spikes are blocked (i.e. when local dendritic TTX application is simulated), neither of the two stimulation protocols we tested was able to induce LTP in the dendritic tuft. We also tested blocking somatic as well as dendritic sodium channels, and found effectively identical results (not pictured). Sample of 10 models with different randomised synapse locations.