Multi-scale modelling of location- and frequency-dependent synaptic plasticity induced by repetitive magnetic stimulation in the dendrites of pyramidal neurons
Fig 7
Voltage traces from local electrical and rMS TBS, recorded at the soma and distal apical tuft, account for the outcomes of synaptic plasticity.
(a) 100 Hz local electrical TBS only causes small somatic voltage depolarisations when inhibition is blocked. (b) 100 Hz local electrical TBS induces dendritic spikes when inhibition is blocked. (c) 100 Hz rMS TBS causes multiple somatic spikes. (d) 100 Hz rMS TBS induces dendritic large-amplitude voltage depolarisations when inhibition is blocked. (e) 100 Hz local electrical TBS causes almost no somatic voltage depolarisation when inhibition is enabled. (f) 100 Hz local electrical TBS does not induce dendritic spikes when inhibition is enabled. (g) 100 Hz rMS TBS causes multiple somatic spikes with inhibition enabled. (h) 100 Hz rMS TBS induces dendritic large-amplitude depolarisations even when inhibition is enabled.