Multi-scale modelling of location- and frequency-dependent synaptic plasticity induced by repetitive magnetic stimulation in the dendrites of pyramidal neurons
Fig 6
The synaptic plasticity model reproduces distal LTP for local electric TBS and predicts proximal and distal LTP for rMS TBS.
Induction of LTP by local electrical TBS to the perforant path. (a): Schematic of local electric stimulation for panels b and c. L-M: lacunosum-moleculare (perforant path target). (b): Negligible plasticity observed when inhibition is present. (c): Distal LTP observed when inhibition is blocked. (d): Schematic of rMS simulation with electric field vector for panels e and f. (e): LTP in both distal and proximal synapses when rMS is used. Unlike local electrical TBS, rMS TBS is able to induce large LTP when inhibition is present. (f): LTP in both distal and proximal synapses when rMS is simulated and inhibition is blocked.