IsRNAcirc: 3D structure prediction of circular RNAs based on coarse-grained molecular dynamics simulation
Fig 6
A representative prediction for junction-circular RNAs.
(A) Predicted 2D structure of SLC22A23 consisting of 259 nucleotides (circRNA ID: hsa_circ_0075504), in which the BSJ is located in the 3-way junction loop (marked by red arrow). (B) Superposition of the initial linear 3D structure (colored by light brown) and the predicted 3D structure of SLC22A23 by IsRNAcirc (colored by light blue). (C-D) Zoom-in show the local details of 3D models: (C) the presence of base collision in the initial 3D structure and (D) the corresponding segments in the 3D model predicted by IsRNAcirc. The atoms carbon, oxygen, and nitrogen are colored by silver, red, and blue, respectively.