IsRNAcirc: 3D structure prediction of circular RNAs based on coarse-grained molecular dynamics simulation
Fig 3
A representive prediction for helix-circular RNAs.
(A) Predicted 2D structure of POLR2A consisting of 336 nucleotides (circRNA ID: hsa_circ_0000741), in which the BSJ is located in the helical region (marked by red arrow). (B) Superposition of the initial linear 3D structure (colored by light brown) and the predicted 3D structure of POLR2A circular RNA by IsRNAcirc (colored by light blue). (C-D) Zoom-in show the local details of 3D models: (C) the presence of template-free loop in the initial 3D structure and (D) the corresponding segment in the predicted 3D model by IsRNAcirc. The atoms carbon, oxygen, and nitrogen are colored by silver, red, and blue, respectively.