Credibility assessment of in silico clinical trials for medical devices
Fig 3
Possibilities for cohort validation (not comprehensive).
Equality sign with question mark indicates "Compared as part of validation activity”. (a) N subject-specific virtual patients each individually validated against data from the corresponding real-world subjects. (b) Distribution of a model output across the virtual cohort validated against corresponding data from the real-world population. (c) Results of an ISCT directly compared to a real-world clinical trial.