GeneCOCOA: Detecting context-specific functions of individual genes using co-expression data
Fig 3
GeneCOCOA recovers functionally relevant terms from single-cell sequencing data. (A) Single cell sequencing data of endothelial cells after myocardial infarction [39] was analyzed with GeneCOCOA, taking (B) Ldlr, which is involved in lipid metabolism, and (C) Tgfb2, an inducer of epithelial- and endothelial-to-mesenchymal transition, as exemplary genes-of-interest. (D) Ldlr shows strong associations with Adipogenesis and mTORC1 signalling. (E) Tgfb2 was linked to Epithelial-to-mesenchymal transition.