Improved detection of microbiome-disease associations via population structure-aware generalized linear mixed effects models (microSLAM)
Fig 5
Investigation of F. prausnitzii fructoselysine PTS system operon.
A) 52 representative genomes selected from NCBI and colored by the dRep secondary cluster (Selection of Faecalibacterium prausnitzii genomes, Methods). B) Comparison of S. Typhimurium operon to operon in F. prausnitzii D. C) Graphic of the F. prausnitzii fructoselysine PTS system operon and its products (made in BioRender). D) P-values for F. prausnitzii fructoselysine PTS system operon genes in microSLAM β tests across the four F. prausnitzii species defined by UHGG. The flanking genes are much less significant than the genes within the operon. Subunit D (most significant gene in microSLAM analysis) is located at 0, and all other indices are relative to this gene.