Agent-based model predicts that layered structure and 3D movement work synergistically to reduce bacterial load in 3D in vitro models of tuberculosis granuloma
Fig 5
The mean distance from macrophages to nearest a) T cells, b) activated T cells, c) activated CD4+ T cells, and activated CD8+ T cells. Each dot represents an average of all cells in a single simulation. The distribution of the mean distances across the set of simulations is compared between spheroid and traditional at day 4. e) A slice through the center of a representative spheroid simulation from the DC-1 simulations at day 4 colored by cell type. f) The same simulation with macrophages in blue, activated T cells enlarged and in yellow, and all other cells in grey. ** p< = 1e-2, **** p< = 1e-4.