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Improved protein complex prediction with AlphaFold-multimer by denoising the MSA profile

Fig 4

MMscore vs confidence for all 7 complexes using 100 iterations per complex (n = 700) from the CASP15 set.

The learning rate (lr) is increasing row-wise and the number of recycles column-wise. The Spearman correlations (R) are displayed in the figure legend. Some correlations are negative. The best correlation (0.68) is obtained by using lr = 0.0001 and 0 recycles.

Fig 4

doi: https://doi.org/10.1371/journal.pcbi.1012253.g004