Emergent effects of synaptic connectivity on the dynamics of global and local slow waves in a large-scale thalamocortical network model of the human brain
Fig 7
Mixed global (Type I) and local (Type II) Slow Waves: Connections greater than 10mm reduced 5-fold.
A) Ten cortical areas with a 5mm radius, that were used to calculate local dynamics. B) Average membrane voltage of layer II neurons. C-E) For each region in (A), subpanels show (C) the single-cell voltage for two neurons in the area, (D) the local field potential (LFP) for the 5mm area, and (E) heatmap of individual voltages of all neurons in the area. This demonstrates that while there is some alignment, up states are not strongly global. F) Latency map, calculated as the onset delay of each neuron with respect to the earliest onset, for each Up state. Note, that while some Up states are global (characteristic examples are marked by blue lines), others are comprised of several independent but coinciding local events (examples are marked by yellow lines).