Emergent effects of synaptic connectivity on the dynamics of global and local slow waves in a large-scale thalamocortical network model of the human brain
Fig 3
Effect of connection density on SO dynamics.
A) Example target cortical column (yellow) with all columns connected to it through any layer (green) for different connection densities. Density is reduced by decreasing P, which denotes the probability of preserving a connection from the original dMRI-based connectivity. With P = 1 all connections are preserved, while for P = 0.5, P = 0.3 and P = 0.1 each connection is preserved with a 50%, 30% or 10% probability, respectively. B) Percent of the original number of connections retained for different values of P. C) Distribution of connection distances, or lengths, for different values of P. Red horizontal lines indicate medians, bottom and top box edges indicate the 25th and 75th percentiles, respectively, whiskers extend to the most extreme data points not considered outliers, and outliers are plotted individually using the ‘+’ marker symbol. Note, connection density is reduced uniformly across all lengths. D-E) Individual analysis of SO dynamics for different values of P. Subpanels as in Fig 2. F) Summary of the effect of reducing connection density on the global SO frequency and amplitude as well as the standard deviation of the onset/offset delays (i.e. the width of the onset/offset histograms in d.5 / e.5).