Strong association between genomic 3D structure and CRISPR cleavage efficiency
Fig 4
3D features rank highly compared to classic features.
Ranks of features used in the LASSO and xgboost models, averaged over the 1000 iterations; a higher rank indicates a more important feature. The 3D feature and classic features are marked with an orange/blue dot, respectively. (A) Number of times each feature was selected in the LASSO models. (B) Feature rank based on LASSO permutation importance. (C) Feature rank based on SHAP values of the xgboost models. (D) Feature rank based on xgboost permutation importance. (E) Feature rank based on xgboost “gain” importance.