Reliable ligand discrimination in stochastic multistep kinetic proofreading: First passage time vs. product counting strategies
Fig 6
The channel capacities in product-based (blue squares) and first activation time-based (red dots) discrimination as a function of processing time τ for various cell contact times T.
We evaluate the channel capacity using stochastic simulations (Gillespie algorithm) of the model in Eq (4) with parameters ,
,
, and kp = 1. The production rate was set higher for easier simulation of the product concentration.