Reliable ligand discrimination in stochastic multistep kinetic proofreading: First passage time vs. product counting strategies
Fig 5
The channel capacity as a function of cell-cell contact time T for first-passage-time-based (FPT-based) signaling and product-based signaling.
The channel capacity is evaluated between the input ξ indicating correct (1) or incorrect (0) substrate and the output Xa or P(T). We assumed ,
,
, τ = 3, and
for a slow product formation rate.