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Reliable ligand discrimination in stochastic multistep kinetic proofreading: First passage time vs. product counting strategies
Fig 4
Statistics of the FPT-based strategy in the TCR recognition scenario.
(A) Accuracy 
as a function of processing time τ and contact duration T, evaluated using Eq (10). (B) The maximal accuracy 
(squares) as a function of processing time τ, evaluated using Eq (12). The asymptotic behavior of 
in the τ → ∞ limit, evaluated using Eq (13), is shown by the dashed curve. In (A,B), we set 
, k−1 = 1, and 
.
doi: https://doi.org/10.1371/journal.pcbi.1012183.g004