HPVsim: An agent-based model of HPV transmission and cervical disease
Fig 1
Infection and progression dynamics for types 16, 18, Hi5 (a pooled group consisting of types 31, 33, 45, 52, and 58), and OHR (a pooled group consisting of 35, 39, 51, 56, and 59).
(A) The duration of HPV infection prior to either clearance or the onset of high-grade squamous intraepithelial lesions (HSIL) follows a log-normal distribution, with parameter values varying by genotype. (B) The mean relationship between the duration of infection, genotype, and the probability of developing precancer. (C) The duration of precancer prior to either clearance or the onset of cancer follows a log-normal distribution, with parameter values varying by genotype. (D) The probability that precancer lasting for at least X years will lead to cancer at the end of the duration drawn from the distribution in panel C.