Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptors
Table 4
Dissociation equilibrium constants for the initial binding to form binary complexes and the cross-linking to form ternary complexes.
Values are calculated from the binding rate constants (Table 2) via KD = koff / kon. The antibodies share the same equilibrium constants due to the assumptions made in the parameter optimization.