Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptors
Table 2
Binding rate constants estimated from IL-6Rα and IL-8RB HEK 293T cell surface binding assays.
S.D. = standard deviation of log-transformed optimized values. α = 8.3 × 10−7 nM/(# / cell) is used to convert the rate constants between nM and number of receptors per cell. The derivation of this value for the unit conversion is included in the Supporting Information (S1 File).