Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptors
Fig 4
Simulations illustrate the dynamics of BS1 antibody binding to IL-6R and IL-8R over time.
Initial BS1 concentration = 100 nM and 105 cells/well for all simulations. Free (unbound) BS1 concentration was set to 0 nM at 2 hours to simulate antibody washout from the system. The expression levels of IL-6R and IL-8R from the transduced experimental cell lines (Table 1) were used in the simulations. Simulation results for additional antibodies and antibody concentrations are included in the Supporting Information (S8 Fig).