Modeling dynamics of acute HIV infection incorporating density-dependent cell death and multiplicity of infection
Fig 3
Standard viral dynamics model and Macroparasite model.
A) Schematic of the standard model. Target cells, T are sourced at rate s and die at rate d. Virus V infects target cells at rate β. Infected cells, I die at rate δ and produce virions at rate p. Free virus gets cleared at rate c. B) Schematic of the Macroparasite model. Target cells, Hi are produced at a constant rate a and die at rate b. Target cells can be uninfected or infected with i virions. Here we demonstrate cells infected with up to 2 virions. Free virus infects target cells at rate β. Virus-induced mortality of infected cells is αi. Infected cells produce free virus at rate λi. Virus gets cleared at rate η. In these schematics, c and η represent the same parameter, viral clearance. We choose to keep them separate to avoid confusion and remain consistent with previous publications.