Machine learning and multi-omics data reveal driver gene-based molecular subtypes in hepatocellular carcinoma for precision treatment
Fig 3
Different biological properties of the two subtypes.
(A-C) Differential analysis of KEGG, Hallmark and oncogenic signature pathways between these two subtypes. (D) The immune cell abundance in these two subtypes using TIMER, with statistical significance assessed by the Mann-Whitney U test. (E) Box plots depicting the expression levels of six immune checkpoint genes in these two subtypes, with red boxes indicating significantly differentially expressed genes (p.adjust < 0.05, |log2FC| > 1). (F) Box plot showing the mRNA stemness scores (mRNAsi) of the two subtypes.